Bundee Aki, Quinn Roux, Kieran Marmion and Jack Carty have all been named in the Ireland matchday 23 to face Wales in the Guinness Six Nations on Saturday.
For the 10th Six Nations game in a row Aki starts at inside centre, while Roux will be looking to build on his caps against England, Scotland and Italy earlier in the campaign.
He's named among the replacements which also includes Kieran Marmion who looks set to win his first Ireland cap since the victory over the All Blacks, and Jack Carty who has made substitute appearances against Italy and France.
Rory Best will lead the team out on his 64th and final 6 Nations appearance with Cian Healy and Tadgh Furlong packing down alongside him in the front row. Tadgh Beirne and James Ryan are partnered in the second row with Peter O’Mahony, Sean O’Brien and CJ Stander named in the backrow.
Conor Murray and Johnny Sexton are named in the pivot positions with Garry Ringrose partnering Bundee Aki for a seventh occasion. Rob Kearney returns to the backfield and is joined by Keith Earls and Jacob Stockdale who fill the wing berths.
The replacements are Niall Scannell, Dave Kilcoyne, Andrew Porter, Quinn Roux, Jack Conan, Kieran Marmion, Jack Carty and Jordan Larmour. Ireland vs Wales, 2019 Guinness Six Nations Championship, Principality Stadium, Saturday 16th March, KO 2.45pm
15. Rob Kearney (UCD/Leinster) 89 caps
14. Keith Earls (Young Munster/Munster) 76 caps
13. Garry Ringrose (UCD/Leinster) 19 caps
12. Bundee Aki (Galwegians/Connacht) 16 caps
11. Jacob Stockdale (Lurgan/Ulster) 18 caps
10. Jonathan Sexton (St Marys College/Leinster) 82 caps (vc)
9. Conor Murray (Garryowen/Munster) 71 caps
1. Cian Healy (Clontarf/Leinster) 87 caps
2. Rory Best (Banbridge/Ulster) 116 caps (c)
3. Tadhg Furlong (Clontarf/Leinster) 32 caps
4. Tadhg Beirne (Lansdowne/Munster) 4 caps
5. James Ryan (UCD/Leinster) 16 caps
6. Peter O’Mahony (Cork Constitution/Munster) 56 caps (vc)
7. Sean O’Brien (UCD/Leinster) 55 caps
8. CJ Stander (Shannon/Munster) 30 caps
16. Niall Scannell (Dolphin/Munster) 13 caps
17. Dave Kilcoyne (UL Bohemians/Munster) 28 caps
18. Andrew Porter (UCD/Leinster) 13 caps
19. Quinn Roux (Galwegians/Connacht) 11 caps
20. Jack Conan (Old Belvedere/Leinster) 13 caps
21. Kieran Marmion (Galwegians/Connacht) 24 caps
22. Jack Carty (Buccaneers/Connacht) 2 caps
23. Jordan Larmour (St Mary’s College/Leinster) 12 caps