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Kieran Marmion starts for Ireland against Japan in the final Test of the summer tour in Tokyo on Saturday (kick-off 2.40pm local time/6.40am Irish time) with John Cooney poised to make his international debut and Tiernan O'Halloran also among the replacements.
Meath man Devin Toner, who made his debut against Samoa in November 2010, is set for his 50th Test appearance in the second row. He is the eighth lock to hit the half-century for Ireland, joining a select group which includes Moss Keane, Donal Lenihan, Paddy Johns, Willie John McBride, Malcolm O'Kelly, Donncha O'Callaghan and Paul O'Connell.
Toner will be partnered in the engine room by Kieran Treadwell who won his first cap off the bench during last week's 50-22 win over Japan. At 21, he is Ireland's second youngest starting lock of the professional era. Bob Casey, who made his bow against England in 2000, beats him by just 28 days.
Head coach Joe Schmidt has made six changes in personnel for the rematch with the Brave Blossoms, along with two positional switches. Treadwell and Leinster hooker James Tracy come in for their first starts up front.
The side is captained again by Rhys Ruddock who is joined in an all-Leinster back row by number 8 Jack Conan, who has scored in both tour games so far, and Josh van der Flier who returns at openside flanker.
Tracy, Cian Healy, who is set for his 70th cap, and John Ryan, who will make his third start of the tour, will join forces in the front row. That means the Munster tighthead will have played in all eight of Ireland's Tests in 2017, including five appearances as a replacement during the Six Nations.
The selected back-line sees Ulster duo Luke Marshall and Jacob Stockdale slot back in at outside centre and on the left wing respectively. Marshall pairs up with Garry Ringrose, while Stockdale's inclusion sees record breaker Keith Earls revert to the right wing and Andrew Conway takes over the full-back position vacated by Simon Zebo who has some fluid on his knee. Dan Leavy (head wound) and Luke McGrath (eye) also have slight knocks.
Paddy Jackson, who has scored 185 points in his Ireland career to date, will win his 25th cap this weekend when he starts at half-back alongside Connacht's Marmion.
Marmion's fellow scrum half Cooney could become the eighth and final debutant of the tour. He is listed on a bench which also contains brothers Niall and Rory Scannell, Dave Kilcoyne, Andrew Porter, James Ryan, Sean Reidy, who is set to add to his first cap won a year ago in South Africa, and O'Halloran.
Saturday's rematch between Ireland and Japan kicks off at 2.40pm local time/6.40am Irish time and will be broadcast live on eir Sport 2 in Ireland and Premier Sports in the UK.
IRELAND Team & Replacements (v Japan, 2017 Summer Tour Second Test, Ajinomoto Stadium, Tokyo, Saturday, June 24, kick-off 2.40pm local time/6.40am Irish time):
Player/Club/Province/Caps -
15. Andrew Conway (Garryowen/Munster) 2
14. Keith Earls (Young Munster/Munster) 61
13. Garry Ringrose (UCD/Leinster) 10
12. Luke Marshall (Ballymena/Ulster) 10
11. Jacob Stockdale (Belfast Harlequins/Ulster) 1
10. Paddy Jackson (Dungannon/Ulster) 24
9. Kieran Marmion (Corinthians/Connacht) 15
1. Cian Healy (Clontarf/Leinster) 69
2. James Tracy (UCD/Leinster) 3
3. John Ryan (Cork Constitution/Munster) 8
4. Kieran Treadwell (Ballymena/Ulster) 1
5. Devin Toner (Lansdowne/Leinster) 49
6. Rhys Ruddock (St. Mary's College/Leinster) (capt) 15
7. Josh van der Flier (UCD/Leinster) 8
8. Jack Conan (Old Belvedere/Leinster) 3
Replacements:
16. Niall Scannell (Dolphin/Munster) 6
17. Dave Kilcoyne (UL Bohemians/Munster) 19
18. Andrew Porter (UCD/Leinster) 1
19. James Ryan (UCD/Leinster) 1
20. Sean Reidy (Belfast Harlequins/Ulster) 1
21. John Cooney (Connacht) *
22. Rory Scannell (Dolphin/Munster) 2
23. Tiernan O'Halloran (Buccaneers/Connacht) 5
* Denotes uncapped player
