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The Eagles were trailing by just one point at half time (14 - 13) after a Niyi Adolokun try and 8 points from outhalf Conor McKeon (2 pens; 1 con).
But the experienced Munster side had too much for the Eagles in the second half as Ivan Dineen, Andrew Conway and James Cronin all crossed for tries to add to earlier first half scores from Sean Dougall and Rory Scannell. JJ Hanrahan kicked four from five conversions.
This was the first interpro defeat of the season for the Eagles after winning both home and away to Ulster Ravens and at home to Leinster 'A'.