This is the first international start for 33-year-old tighthead prop White who made his cameo appearance in an Ireland jersey two weeks ago against Scotland.
Paul O'Connell returns to captain the side in his last international on home soil and is partnered in the second row by Iain Henderson. Jamie Heaslip starts at No.8 with Peter O'Mahony lining out on the blind-side flank and Jordi Murphy filling the open-side berth. White is joined in the front row by Jack McGrath and Richardt Strauss.
Conor Murray and Johnny Sexton pair up at half-back with Robbie Henshaw and Luke Fitzgerald lining out in the centre. The back three consists of Keith Earls, Dave Kearney with Rob Kearney at fullback.
Among the replacements are Sean Cronin, Dave Kilcoyne, Tadhg Furlong, Donnacha Ryan, Sean O'Brien, Eoin Reddan, Paddy Jackson and Felix Jones.
Tickets remain available for Ireland's final home game of the Guinness Summer Series. Tickets are available from www.ticketmaster.ie
IRELAND team to play Wales – Saturday 29th August, 2015
15. Rob Kearney (UCD/Leinster)
14. Dave Kearney (Lansdowne/Leinster)
13. Luke Fitzgerald (Blackrock/Leinster)
12. Robbie Henshaw (Buccaneers/Connacht)
11. Keith Earls (Young Munster/Munster)
10. Johnny Sexton (St Marys/Leinster)
9. Conor Murray (Garryowen/Munster)
8. Jamie Heaslip (Dublin University/Leinster)
7. Jordi Murphy (Lansdowne/Leinster)
6. Peter O'Mahony (Cork Con/Munster)
5. Paul O'Connell (Young Munster) capt
4. Iain Henderson (Ballynahinch/Ulster)
3. Nathan White (Connacht)
2. Richardt Strauss (Old Wesley/Leinster)
1. Jack McGrath (St. Mary's/Leinster)
16. Sean Cronin (St Mary's/Leinster)
17. Dave Kilcoyne (UL Bohemians/Munster)
18. Tadhg Furlong (Clontarf/Leinster)*
19. Donnacha Ryan (Shannon/Munster)
20. Sean O'Brien (UCD/Leinster)
21. Eoin Reddan (Old Crescent/Leinster)
22. Paddy Jackson (Dungannon/Ulster)
23. Felix Jones (Shannon/Munster)
*Denotes uncapped player